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Researchers have created a mutant worm that can never get drunk.

They inserted a molecule that can completely block the effects on alcohol into the Caenorhabditis elegans.

The tiny worm was chosen because it loses the ability to wiggle when drunk.

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The worms used in the study, Caenorhabditis elegans slow their crawling with less wriggling from side to side when drunk

The University of Texas at Austin scientists accomplished this feat by inserting a modified human alcohol target into the worms, as reported this week in The Journal of Neuroscience.

Jon Pierce-Shimomura, who led the research, said it could even be used to develop a 'James Bond' drug someday, which would enable a spy to drink his opponent under the table, without getting drunk himself.

Such a drug could also potentially be used to treat alcoholics, since it would counteract the intoxicating and potentially addicting effects of the alcohol.

'This is the first example of altering a human alcohol target to prevent intoxication in an animal,' he said.

An alcohol target is any neuronal molecule that binds alcohol, of which there are many.

One important aspect of this modified alcohol target, a neuronal channel called the BK channel, is that the mutation only affects its response to alcohol.

The BK channel typically regulates many important functions including activity of neurons, blood vessels, the respiratory tract and bladder.

The alcohol-insensitive mutation does not disrupt these functions at all.

'We got pretty lucky and found a way to make the channel insensitive to alcohol without affecting its normal function,' says Pierce-Shimomura.

when sober, the Caenorhabditis elegans worm is able to wiggle (left), but once intoxicated, it straightens up.

The scientists believe the research has potential application for treating people addicted to alcohol.

'Our findings provide exciting evidence that future pharmaceuticals might aim at this portion of the alcohol target to prevent problems in alcohol abuse disorders,' says Pierce-Shimomura.

'However, it remains to be seen which aspects of these disorders would benefit.'

Unlike drugs such as cocaine, which have a specific target in the nervous system, the effects of alcohol on the body are complex and have many targets across the brain.

The various other aspects of alcohol addiction, such as tolerance, craving and the symptoms of withdrawal, may be influenced by different alcohol targets.

The worms used in the study, Caenorhabditis elegans, model intoxication well.

Researchers saif the work could even be used to develop a 'James Bond' drug someday, which would enable a spy to drink his opponent under the table, without getting drunk himself.

Alcohol causes the worms to slow their crawling with less wriggling from side to side.

The intoxicated worms also stop laying eggs, which build up in their bodies and can be easily counted.

Unfortunately, C. elegans are not as ideal for studying the other areas of alcohol addiction, but mice make an excellent model.

The modified human BK channel used in the study, which is based on a mutation discovered by lead author and graduate student Scott Davis, could be inserted into mice.

These modified mice would allow scientists to investigate whether this particular alcohol target also affects tolerance, craving and other symptoms relevant to humans.