Left between life and death: First 'suspended animation' trials set to begin in bid to buy time for stabbing and gunshot victims


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Han Solo from Star Wars was frozen in suspended animation for transport, but now scientists hope to perform surgery by 'freezing' patients

Han Solo from Star Wars was frozen in suspended animation for transport, but now scientists hope to perform surgery by 'freezing' patients

It sounds like something out of Star Wars - doctors are to attempt to save the lives of ten patients by putting them in 'suspended animation', when they are neither alive or dead.

Surgeons at UPMC Presbyterian Hospital in Pittsburgh will cool down the patients so their blood cells need less oxygen to survive.

While the body is in this state, the team will work to fix the 'structural problems' caused by a blade or a bullet.

The trial will take place later this month and the surgeons are already on call at the hospital, primed for when a suitable patient arrives.

Because the patients will be unable to give consent to the procedure, researchers have been running a publicity campaign to allow potential patients to opt out.

Locals have been able to order bracelets to indicate that they don't consent.

The procedure - which has been likened to what happened to Hans Solo in the Star Wars movie -  will see all of the patients' blood being replaced with cold saline solution, meaning their bodies will quickly cool to 10C and almost all cellular activity will stop.

'We are suspending life, but we don't like to call it suspended animation because it sounds like science fiction,' Samuel Tisherman, a surgeon at the hospital, told New Scientist.

'So we call it emergency preservation and resuscitation.'

 

Peter Rhee at the University of Arizona added: 'If a patient comes to us two hours after dying you can't bring them back to life.

'But if they're dying and you suspend them, you have a chance to bring them back after their structural problems have been fixed.'


It has long been known that there are benefits to cooling the bodies of some severely injured people.

When the body is at its normal temperature, cells need a strong supply of oxygen, meaning that if the heart stops beating, the person will die rapidly.

However, if the body temperature has been reduced, less oxygen is required, buying doctors time to save the patient.

Previously, cooling of a body has been used during some operations but this involves circulating the blood through a cooling system.

HOW IT WILL WORK

The study is a feasibility and safety study designed to see if hypothermia is beneficial.

In EPR, body temperature is lowered to about 50ºF (10ºC) by administering a large volume of cold fluid through a large tube, called a cannula, placed into the aorta, which is the largest artery in the body.

A heart-lung bypass machine would be used to restore blood circulation and oxygenation as part of the resuscitation process.

The study will be conducted at the University of Pittsburgh and the University of Maryland. 

This is not an option in emergency medicine as it takes too long.

As a result, doctors had to find a method of cooling the body much more quickly.

In 2002 researchers at the University of Michigan tested a new technique on pigs.

The creatures were sedated and then subjected to massive blood loss before their blood was replaced by cold saline solution.

Once the pigs had been cooled to 10C, their injuries were repaired and they were warmed up again.

A cell in suspended animation. Doctors face the challenge of freezing human cells without causing damage

A cell in suspended animation. Doctors face the challenge of freezing human cells without causing damage

The saline solution was replaced by their blood.

The researchers noted that in most of the pigs, the hearts started again naturally and they suffered no long-term ill effects.

The medics are now ready to try the technique on humans.

However, they will need the right patient.

Surgeons at UPMC Presbyterian Hospital, in Pittsburgh, will cool down the patients so their blood cells need less oxygen to survive.

Surgeons at UPMC Presbyterian Hospital, in Pittsburgh, will cool down the patients so their blood cells need less oxygen to survive.

It will have to be someone whose heart has stopped as a result of an injury and who cannot be successful revived using traditional techniques.

Their body temperature will be reduced in just 15 minutes, they will temporarily have no blood in their system and they will not be breathing or have any brain activity.

Technically, they will be dead.

The doctors hope that the patients will then revive naturally but if they do not then they will be resuscitated.



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